AskDefine | Define cerebrum

Dictionary Definition

cerebrum n : anterior portion of the brain consisting of two hemispheres; dominant part of the brain in humans [also: cerebra (pl)]

User Contributed Dictionary



cerebrum (plural cerebra or cerebrums)
  1. The upper part of the brain, which is divided into the two cerebral hemispheres. In humans it is the largest part of the brain and is the seat of motor and sensory functions, and the higher mental functions such as consciousness, thought, reason, emotion, and memory.



The upper part of the brain
  • Czech: koncový mozek
  • Dutch: telencephalon
  • Finnish: isot aivot
  • Russian: головной мозг

Extensive Definition

The telencephalon (), cerebrum, or forebrain is the most anterior or, especially in humans, most dorsal region of the vertebrate central nervous system. "Telencephalon" refers to the embryonic structure, from which the mature "cerebrum" develops. The dorsal telencephalon, or pallium, develops into the cerebral cortex, and the ventral telencephalon, or subpallium, becomes the basal ganglia. The cerebrum is also divided into symmetric left and right cerebral hemispheres.


During vertebrate embryonic development, the prosencephalon, the most anterior of three vesicles that form from the embryonic neural tube, is further subdivided into the telencephalon and diencephalon. The telencephalon then forms two lateral telencephalic vesicles which develop into the left and right cerebral hemispheres.


The cerebrum is composed of the following sub-regions:


The cerebrum comprises what most people think of as the "brain." It lies in front or on top of the brainstem and in humans is the largest and most well-developed of the five major divisions of the brain. The cerebrum is the newest structure in the phylogenetic sense, with mammals having the largest and most well-developed among all species. In larger mammals, the cerebral cortex is folded into many gyri and sulci, which has allowed the cortex to expand in surface area without taking up much greater volume. See also Cerebral Cortex.
In humans, the cerebrum surrounds older parts of the brain. Limbic, olfactory, and motor systems project fibers from the cerebrum to the brainstem and spinal cord. Cognitive and volitive systems project fibers from the cerebrum to the thalamus and to specific regions of the midbrain. The neural networks of the cerebrum facilitate complex behaviors such as social interactions, learning, working memory, and in humans, speech and language.


Note: As the cerebrum is a gross division with many subdivisions and sub-regions, it is important to state that this section lists the functions that the cerebrum as a whole serves. See main articles on cerebral cortex and basal ganglia for more information.


The cerebrum directs the conscious or volitional motor functions of the body. These functions originate within the primary motor cortex and other frontal lobe motor areas where actions are planned. Upper motor neurons in the primary motor cortex send their axons to the brainstem and spinal cord to synapse on the lower motor neurons, which innervate the muscles. Damage to motor areas of cortex can lead to certain types of motor neuron disease. This kind of damage results in loss of muscular power and precision rather than total paralysis.

Sensory Processing

The primary sensory areas of the cerebral cortex receive and process visual, auditory, somatosensory, gustatory, and olfactory information. Together with association cortical areas, these brain regions synthesize sensory information into our perceptions of the world around us.


The olfactory bulb in most vertebrates is the most anterior portion of the cerebrum, and makes up a relatively large proportion of the telencephalon. However, in humans, this part of the brain is much smaller, and lies underneath the frontal lobe. The olfactory sensory system is unique in the sense that neurons in the olfactory bulb send their axons directly to the olfactory cortex, rather than to the thalamus first. Damage to the olfactory bulb results in a loss of the sense of smell.

Language and communication

Speech and language are mainly attributed to parts of the cerebral cortex. Motor portions of language are attributed to Broca's area within the frontal lobe. Speech comprehension is attributed to Wernicke's area, at the temporal-parietal lobe junction. These two regions are interconnected by a large white matter tract, the arcuate fasciculus. Damage to the Broca's area results in expressive aphasia (non-fluent aphasia) while damage to Wernicke's area results in receptive aphasia (also called fluent aphasia).

Learning and Memory

Explicit or declarative (factual) memory formation is attributed to the hippocampus and associated regions of the medial temporal lobe. This association was originally described after a patient known as HM had both his hippocampuses (left and right) surgically removed to treat severe epilepsy. After surgery, HM had anterograde amnesia, or the inability to form new memories. This condition is also portrayed in the film Memento, in which the protagonist has to take pictures of people he has met in order to be able to remember what to do in the days following his accident.
Implicit or procedural memory, such as complex motor behaviors, involve the basal ganglia. Therefore,

Cell regeneration

Xenopus laevis

Larval stage

In a study of the telencephalon conducted in Hokkaido University on African clawed frogs (xenopus laevis)ref Yoshino, it was discovered that, during larval stages, the telencephalon was able to regenerate around half of the anterior portion (otherwise known as partially truncated), after a reconstruction of a would-be accident, or malformation of features.
The regeneration and active proliferation of cells within the clawed frog is quite remarkable, regenerated cells being almost functionally identical to the ones originally found in the brain after birth, despite the lack of brain matter for a sustained period of time.
This kind of regeneration depends on ependymal layer cells covering the cerebral lateral ventricles, within a short period before, or within the initial stage of wound-healing. This is observed within the stages of healing within larvae of the clawed frog.

Developed stage

The regeneration within the developed stage of the clawed frog is different from that in the larval stage. Because the cells adhere to one another, they are unable to form an entity that can cover the cerebral lateral ventricles. Thus, the telencephalon remains truncated and the loss of function becomes permanent.

Effects of abnormality

After removing over half of the telencephalon in the developed stage of the clawed frog, the lack of functions within the animal was apparent, manifesting with obvious difficulties in movement, nonverbal communication between other species, as well as other difficulties thought to be similar to those seen in humans.
This kind of regeneration is still relatively unknown in regard to regeneration within larval stages, similar to the human fetal stage.


  1. Levi-Montalcini, R. (1949) Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions. Pages 450 - 502
  2. note Yoshino Yoshino J, Tochinai S. Successful reconstitution of the non-regenerating adult telencephalon by cell transplantation in Xenopus laevis. Dev Growth Differ. 2004;46(6):523–34. PMID 15610142
  3. note Yaginuma Yaginuma, H., Tomita, M., Takashita, N., McKay, S., Cardwell, C., Yin, Q.- Aminobuytric acid immunoreactivity within the human cerebral cortex. Pages 481 - 500
  4. note Haydar Haydar, T. F, Kuan, C., Y., Flavell, R. A. & Rakic, P. (1999) The role of cell death in regulating the size and shape of the mammalian forebrain. Pages 621 - 626
cerebrum in Arabic: مخ
cerebrum in Danish: Storhjerne
cerebrum in German: Telencephalon
cerebrum in Spanish: Telencéfalo
cerebrum in Esperanto: Cerebro
cerebrum in Persian: مخ
cerebrum in French: Télencéphale
cerebrum in Hebrew: המוח הגדול
cerebrum in Japanese: 大脳
cerebrum in Korean: 대뇌
cerebrum in Latin: Cerebrum
cerebrum in Lithuanian: Galinės smegenys
cerebrum in Dutch: Telencephalon
cerebrum in Norwegian: Telencephalon
cerebrum in Polish: Kresomózgowie
cerebrum in Russian: Конечный мозг
cerebrum in Simple English: Cerebrum
cerebrum in Swedish: Storhjärna
cerebrum in Thai: ซีรีบรัม
cerebrum in Chinese: 大腦

Synonyms, Antonyms and Related Words

arachnoid, arbor vitae, archipallium, between brain, brain stem, cerebellar hemispheres, cerebellum, cerebral cortex, cerebrospinal fluid, convolution, corpus callosum, corpus striatum, diencephalon, dura mater, endbrain, fissure, folia, forebrain, fornix, frontal lobe, glial cells, globus pallidus, gray matter, gyrus, hindbrain, hippocampus, hypothalamus, lenticular nucleus, limbic lobe, little brain, lobe, mantle, medulla oblongata, meninges, mesencephalon, metencephalon, midbrain, myelencephalon, neopallium, occipital lobe, optic chiasm, pallium, parietal lobe, pia mater, pineal body, pituitary body, pons, reticular system, rhombencephalon, subthalamus, telencephalon, temporal lobe, thalamus, ventricle, vermis, white matter
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